منابع مشابه
Forty-Five Years of Marburg Virus Research
In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens. This article provides a comprehensive overview of our current knowledge about Marburg virus disease ranging from ecology to pathogenesis and molecular biology.
متن کاملForty-Five Years of A-stability
We discuss two events with profound implications on the way initial value problems are solved numerically. The first was the identification of stiffness as a widely spread phenomenon affecting the ability to obtain useful results. The second was the definition of A-stability as an important approach to overcoming the effect of stiffness. Not only was the idea associated with A-stability signifi...
متن کاملForty-five years of cell-cycle genetics
In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals f...
متن کاملForty-Five Years of Duchenne Muscular Dystrophy in The Netherlands.
BACKGROUND Duchenne muscular dystrophy (DMD) is a progressive muscle disease. No curative therapy is currently available, but in recent decades standards of care have improved. These improvements include the use of corticosteroids and mechanical ventilation. OBJECTIVE To present a detailed population based report of the DMD disease course in The Netherlands (1980-2006) and evaluate the effect...
متن کاملForty-five years of schizophrenia trials in Italy: a survey
BACKGROUND Well-designed and properly executed randomized controlled trials (RCTs) provide the best evidence on the efficacy of healthcare interventions. Mental health has a strong tradition of using trial to evaluate treatments, but the translation of research to clinical practice is not always easy. Even well-conducted trials do not necessarily address the needs of every day care and trials c...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 1957
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.bi.26.070157.000245